项目文章|oxBS揭示口腔鳞癌的启动子区甲基化和羟甲基化变化及基因差异表达

日期:24-01-25

20231012日,南华大学王丹玲教授和万正卿为共同通讯作者在《Front Genet》杂志发表题为“Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma”的研究论文,该研究利用平行全基因组亚硫酸盐测序(WGBS)和全基因组氧化亚硫酸氢测序(oxWGBS),在成对原发口腔鳞状细胞癌样本及其正常癌旁组织(NATs)中以单核苷酸分辨率表征5mC5hmC图谱,并采用多组学方法分析5mC5hmc修饰对OSCC差异基因表达的影响。易基因科技为本研究提供oxWGBS+WGBS测序分析服务。




参考文献:

Zhao W, Zhu L, Gong Q, Ma S, Xiong H, Su T, Wan Z, Wang D. Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma. Front Genet. 2023;14:1269084. pii: 1269084. doi: 10.3389/fgene.2023.1269084. PubMed PMID: 37900177.